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Publication #6155
Reference
Name
Drug alert: action within 48 hours [Gadolinium Contrast Agents and Risk Of Tissue Accumulation Removal Of Omniscan And Intravenous Magnevist From February; Restrictions To Use Of Other Linear Agents]
Categories
Scottish Government
Drug Alerts
Organization
Scottish Government Health and Social Care Directorates
Keywords
NHS
SCOTLAND
DRUGS
SAFETY
RISKS
PHARMACEUTICAL INDUSTRY
DRUG THERAPY
PHARMACEUTICAL SERVICES
Description
• There is evidence that gadolinium can be retained in the brain and in other organs after administration of gadolinium-containing contrast agents (GdCAs). Linear GdCAs are associated with higher retention of gadolinium in the brain than macrocyclic GdCAs.
• The licences for gadodiamide (Omniscan) and intravenous gadopentetic acid (also known as gadopentetate dimeglumine, Magnevist) will be suspended as of 1 February 2018.
• The authorised indication of the linear agents gadobenic acid (also known as gadobenate dimeglumine, MultiHance) and gadoxetic acid (Primovist) will be limited to delayed phase liver imaging only.
• Macrocyclic agents, gadoteridol (Prohance), gadobutrol (Gadovist) and gadoteric acid (Dotarem, Clariscan, Dotagraf, Cyclolux) will remain authorised, as will gadopentetic acid for intra-articular use.
• The licences for gadodiamide (Omniscan) and intravenous gadopentetic acid (also known as gadopentetate dimeglumine, Magnevist) will be suspended as of 1 February 2018.
• The authorised indication of the linear agents gadobenic acid (also known as gadobenate dimeglumine, MultiHance) and gadoxetic acid (Primovist) will be limited to delayed phase liver imaging only.
• Macrocyclic agents, gadoteridol (Prohance), gadobutrol (Gadovist) and gadoteric acid (Dotarem, Clariscan, Dotagraf, Cyclolux) will remain authorised, as will gadopentetic acid for intra-articular use.
Contact Name
Irene Fazakerley
Contact Email
Contact Address
Pharmacy and Medicines Division, St Andrew's House, Regent Road, Edinburgh, EH1 3DG.
Contact Phone
Created
2017-12-13 00:00:00
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