Publication #8351

Reference
Name
National Patient Safety Alert – Shortage of Pancreatic Enzyme Replacement Therapy (PERT)
Categories
Scottish Government
Organization
Scottish Government Health and Social Care Directorates
Keywords
NHS Scotland Health Boards National Patient Safety Alerts Shortages
Description
This alert contains actions which are in addition to those outlined in the National Patient Safety Alert (NatPSA/2024/007/DHSC) issued on 24th May 2024. 
There are limited supplies of pancreatic enzyme replacement therapies (PERT). 
  • Creon® 10,000 and 25,000 capsules remain in limited supply until 2026. 
  • Nutrizym® 22 capsules and Pancrex V® capsules and powder are intermittently available but are unable to fully cover the gap in supply. 
The supply disruption of Creon® capsules is due to limited availability of raw ingredients and manufacturing capacity constraints to produce volumes needed to meet demand. There are regular deliveries to wholesalers, two to three times each month, of both strengths to allow for equitable distribution. However, the volumes are insufficient to meet full demand. Therefore out of stock periods continue between each delivery. 
Production of Nutrizym® 22 capsules has been increased and supplies are being released monthly, however this increase is unable to fully cover the gap in supply. There are intermittent deliveries of Pancrex V® capsules and powder but these are also unable to support an uplift. 
Unlicensed imports of Creon® capsules and alternative brands of PERT can be sourced, lead times vary. 

Contact Name
Irene Fazakerley
Contact Email
irene.fazakerley@gov.scot
Contact Address
Contact Phone
0131 244 2528

Created
2024-12-18 08:32:00

Download URL
https://www.publications.scot.nhs.uk/files/dc20241218pert.pdf

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