Diamorphine 5 mg and 10 mg powder for solution for injection ampoules are currently out of stock, with no confirmed resupply date. Diamorphine 100 mg powder for solution for injection ampoules are expected to become unavailable from early January 2026, with no current confirmed resupply date. Diamorphine 30mg powder for solution for injection ampoules are currently available but are unable to support any increase in demand. Morphine sulfate injection has been identified by clinical experts as the first-line alternative opioid. Sufficient supplies of morphine sulfate 10mg/ml injection are available from Ethypharm and Hameln to cover the supply gap. During previous shortages of diamorphine, both primary and secondary care organisations were advised to switch to morphine, where clinically appropriate. This should be expedited as a permanent change in practice given the continuing unpredictable supply of diamorphine.